Dimethocaine Hydrochloride, CAS: 553-63-9

New Anti-pain drugs Dimethocaine Hydrochloride Local Anesthetic Larocaine HCL Pharmaceutical Raw powder

Dimethocaine Hydrochloride Basic information

Product Name: Dimethocaine Hydrochloride
Synonyms: Larocaine hydrochloride;Dimethocaine hydrochloride;Larocaine HCl;
cas: 553-63-9
MF: C16H26N2O2.ClH
MW: 314.854
Melting point 195-196℃
Dimethocaine Hydrochloride Usage And Synthesis
Chemical Properties Off-White Solid
Uses A local anesthetic with stimulant properties. Studies have shown its potency to be about half that of Cocaine (C633500).
Uses Dimethocaine is a local anesthetic that, because of its similarity in action to cocaine, has potential for abuse. This compound completely inhibits dopamine uptake in rat striatal synaptosomes with an IC50 value of 1.2 μM comparable to that of cocaine (IC50 = 0.7 μM). As a result, dimethocaine dose-dependently substitutes for cocaine in drug discrimination tests in rats and rhesus monkeys. This product is intended for forensic and research purposes.
Description of Dimethocaine Hydrochloride
Dimethocaine (Larocaine) is a local anesthetic with stimulant properties that some studies have shown to be half the potency of cocaine.
When a product sold online in the UK in June 2010, advertised as dimethocaine was tested, it was found to in fact be a mixture of caffeine and lidocaine, and the lack of any dopaminergic stimulant ingredient in such mixes may explain the limited recreational effects reported by many users. Other samples tested have however been shown to contain genuine dimethocaine, and one branded “bath salt” product containing primarily dimethocaine as the active ingredient, was noted to have been particularly subject to abuse by intravenous drug users in Ireland.

Dimethocaine/Larocaine, CAS:94-15-5

Buy Legal pain killer Dimethocaine Local Anesthetic powder new arrival Larocaine

Description of Dimethocaine (Larocaine )

Dimethocaine is derivate from cocaine, it is not a part of the organic alkaloid mix coming from a coca plant. Dimethocaine is very popular research chemical, mainly used as local anesthetic, but also the stimulant qualities appeared to be shown immediately. First of all it actually was explained that dimethocaine only has 10% of the potency because of cocaine, however customer reviews have proven it’s not correct, effects are stronger than expected. The effects act like the ones from cocaine, emotional state lift, euphoria and even stimulation, the results do not appear in a hurry like cocaine, on the other hand last longer.

Dimethocaine optional dosages

Dimethocaine needed for leisure use is normally used for instance like cocaine, insufflated, it really is also easy to take it intravenous. It’s not necessarily recommended to take the unusually high dosage amounts of dimethocaine to obtain a cocaine like rush, that the amount can be excessive it can be considered a main problem for your cardiovascular system. Insufflated a normal the amount of dimethocaine ranges from 100 close to 2 hundred mg, but newbees should start off with lesser levels, suggested are Fifty milligrams.

In e that used intravenous, than the medication dosage could be far lower, however buyers even so use up to A hundred milligrams to reach greater effects.

Experiences and also side-effects

If perhaps dimethocaine was already insufflated, the effects need to have 15-20 min to arrive up. Generally a person begins to really feel a bit extra stimulated plus euphoric, any time sitting a tingling may be felt within the person. The biggest effects last for Three hours, further 2 hours to return to routine. The overall ultimate results are very just like the ones from cocaine, but then they show up bit by bit and are still regular in potency. Habitual cocaine users take a searching for the next usage, after that top as a result of cocaine has moved out. Because of dimethocaine these hungers are typically normal not actually present, only if that drug was consumed intravenous for a extended period and in larger levels.

A daily consumption by having a regular quantity of 100 mg, gets underway with a tiny numbness inside the nose. Dimethocaine is local anaesthetic and for that reason that doesn´t burn, nor it feels not comfortable, right after 3-4 minutes or so the nose area may be a little bit dripping and simply a compound, cocaine like flavor might be experienced in your mouth. After 15-20 min’s final effects begin with a little energetic together with euphoric emotion, people can feel stimulated, ocionally talkativeness is typically an effect at the start.

Top is normally normal reached Twenty to thirty minutes following insufflating dimethocaine, the experiences from the start improve, buyers frequently like activities. Thinkings typically look a lot faster and much easier, a beautiful body feeling and sometimes along with a increased desire for new music and dancing. In contrast to cocaine, dimethocaine offers a steady effect, simply no ups and downs, this will make the experience more comfortable, cause there aren’t any cravings or not comfortable unpredicted changes in results.

Your peak starts to fade Three hours after insufflating, although this too doesn´t take place in a rush, the effects begin to vanish gradually, exactly like the experience started out. Following Four to six hours even all of the following effects have left, often the consumer feels a little tired after the experience.

Side-effects are actually unknown, because the recreational history of dimethocaine is actually short. But it should be expected to get very similar side-effects just like cocaine, so it is not advised for people with cardiovascular diseases and also other health issues. An individual dose of dimethocaine includes typically simply no notable consequences during the next day, having said that ongoing ingestion and also very high dosages may result in hangovers. With the relation to your cardiovascular system, it is really not advised to use increased dosage amounts, sustained consumption or even a intravenous usage. Over the stronger effects of an intravenous injections, dimethocaine might also result in slight cravings, they’re not much like that from cocaine, but still detectable.

Dibucaine hydrochloride, CAS: 61-12-1

Dibucaine hydrochloride HCL Local Anesthetic with best price on hot selling CAS NO.61-12-1

CAS no. : 61-12-1
EINECS no. : 200-498-1
Molecular formula: C20H31Cl2N3O2
Molecular weight: 416.385
Melting point: 99-101 ℃
Boiling point: 544.7 ° C at 760 mmHg
Flash: 283.2 ° C
Vapor pressure: 3.37 e-12 mmHg at 25 ° C
Storage :Store in cool and dry palce. Keep away from strong light ,high temperature.
Usage: Used as a local anesthetic
transportation:by express delivery or sea shipping.
Sample: At any time to provide (lowest price & highest quality)Usage:Anesthetic (local)

Articaine hydrochloride, CAS:23964-57-0

Articaine hydrochloride HCL Local Anesthetic CAS NO.23964-57-0 with high purity

Articaine hydrochloride

CAS NO.23964-57-0
MF: C13H20N2O3S.ClH
MW: 320.839
EINECS: 245-957-7
Product Categories: local anesthetic;Pharmaceutical intermediate
Appearance : White powders
Purity : 99%
Usage: Articaine is a dental local anesthetic. It is the most widely used local anesthetic in a number of European countries and is available in many countries around the world.
Articaine is used for pain control. Like other local anesthetic drugs, articaine causes a transient and completely reversible state of anesthesia (loss of sensation) during (dental) procedures.
In dentistry, articaine is used both for infiltration and block injections, with the block technique yielding the greatest duration of anesthesia.
In people with hypokalemic sensory overstimulation, lidocaine is not very effective, but articaine works well.

Ropivacaine Hydrochloride, CAS: 98717-15-8

Ropivacaine Hydrochloride HCL Local Anesthetic CAS NO.98717-15-8

Ropivacaine hydrochloride
CAS: 98717-15-8
Molecular formula: C17H27ClN2O
Molecular Weight: 310.8621
Boiling point: 438.2 ° C at 760 mmHg
Flash Point: 218.8 ° C
Vapor Pressure: 4.37E-08mmHg at 25 ° C
Assay: 99.8%
Packing: 25kg/drum
Character: White to off-white crystal or crystalline powder
Standard: USP/BP

Product Application:
Ropivacaine is a local anaesthetic drug belonging to the amino amide group. The name ropivacaine refers to both the racemate and the marketed S-enantiomer.Ropivacaine is an anesthetic (numbing medicine) that blocks the nerve impulses that send pain signals to your brain.Ropivacaine is used as a local (in only one area) anesthesia for a spinal block, also called an epidural. The medication is used to provide anesthesia during a surgery or C-section, or to ease labor pains.Ropivacaine may also be used for purposes not listed in this medication guide.

Product Function:
Ropivacaine is indicated for local anaesthesia including infiltration, nerve block, epidural and intrathecal anaesthesia in adults and children over 12 years. It is also indicated for peripheral nerve block and caudal epidural in children 1-12 years for surgical pain. It is also sometimes used for infiltration anaesthesia for surgical pain in children.

Proparacaine hydrochloride, CAS: 5875-06-9

Proparacaine HCL Local Anesthetic Drugs Proparacaine Hydrochloride CAS 5875-06-9

Proparacaine hydrochloride

EINECS: 227-541-7
Boiling Point: 434.4 °C at 760 mmHg
Flash Point: 216.5 °C
CAS: 5875-06-9
MF: C16H27ClN2O3
MW: 330.85
EINECS: 227-541-7
Assay: 99%
Usage: API
Appearance:White crystalline powder
Package:1kg/10kg or on request
Usage Anesthetic;Neuronal conductance inhibitor

Description:
Anesthesia, local- Proparacaine and tetracaine are indicated to produce local anesthesia of short duration for ophthalmic procedures including measurement of intraocular pressure, removal of foreign bodies and sutures, and conjunctival and corneal scraping in diagnosis and gonioscopy.
Applications:
Proparacaine hydrochloride and tetracaine are also indicated to produce local anesthesia prior to surgical procedures such as cataract extraction and pterygium excision, usually as an adjunct to locally injected anesthetics.
Ophthalmic solutions used for intraocular procedures should be preservative-free. Preservatives may cause damage to the corneal epithelium if a significant quantity of solutionenters the eye through the incision.

Applications:
Proparacaine hydrochloride and tetracaine are also indicated to produce local anesthesia prior to surgical procedures such as cataract extraction and pterygium excision, usually as an adjunct to locally injected anesthetics.
Ophthalmic solutions used for intraocular procedures should be preservative-free. Preservatives may cause damage to the corneal epithelium if a significant quantity of solution enters the eye through the incision.

Levobupivacaine Hydrochloride, CAS:27262-48-2

Levobupivacaine HCL Pain-Relieving Local Anesthetic powder Levobupivacaine Hydrochloride

Levobupivacaine hydrochloride
CAS:27262-48-2
MF:C18h29cln2o
MW:324.89
Purity: 99%
Storage instructions:Store at -20°C (desiccating conditions)
Appearance: White crystalline powder
product categories:Pharmaceutical raw materials;Active pharmaceutical ingredients
chemical properties:White crystalline powder
usage:Anesthetic;Na+ channel inhibitor.
Packaging details 25kg/drum,1kg/foil bag

Description:

Levobupivacaine (rINN) is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine.
The hydrochloride salt of levobupivacaine, an amide derivative with anesthetic property. Levobupivacaine reversibly binds voltage-gated sodium channels to modulate ionic flux and prevent the initiation and transmission of nerve impulses (stabilizing neuronal membrane), thereby resulting in analgesia and anesthesia. In comparison with racemic bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action.

Applications:

Levobupivacaine is the S-enantiomer of bupivacaine hydrochloride and is chemically described as (S)-1-butyl-2-piperidylformo-2′, 6′-xylidide hydrochloride.
Levobupivacaine is a member of the amino amide class of local anaesthetics. It is indicated for surgical anesthesia and postoperative pain management.

Bupivacaine Hydrochloride, CAS: 14252-80-3

Bupivacaine HCL Pain Killer Local Anesthetic Bupivacaine Hydrochloride Raw Powder

Quick detail:
Name: Bupivacaine hydrochloride
CAS: 14252-80-3
EINECS number: 241-917-8
Molecular formula: C18H31ClN2O2
Molecular Weight: 342.9039
Boiling point: 423.4 ° C at 760 mmHg
Flash Point: 209.9 ° C
Vapor Pressure: 2.24E-07mmHg at 25 ° C
Product use: After local anesthesia for surgery and postoperative analgesia

Description:
Anesthesia, local- Proparacaine and tetracaine are indicated to produce local anesthesia of short duration for ophthalmic procedures including measurement of intraocular pressure, removal of foreign bodies and sutures, and conjunctival and corneal scraping in diagnosis and gonioscopy.

Applications:
Proparacaine hydrochloride and tetracaine are also indicated to produce local anesthesia prior to
surgical procedures such as cataract extraction and pterygium excision, usually as an adjunct to locally injected anesthetics. Ophthalmic solutions used for intraocular procedures should be preservative-free.
Preservatives may cause damage to the corneal epithelium if a significant quantity of solutionenters the eye through the incision.

Linocaine Hydrochloride, CAS: 6108-05-0

Linocaine HCL Local Anesthetic Drugs Linocaine Hydrochloride Anti-pain Pharmaceutical Material CAS 6108-05-0

Linocaine Hydrochloride
Synonym: ACETAMIDE,2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)-MONOHYDROCHLORIDE, MONOHYDRATE;LINOCAINE HYDROCHLORIDE;LIDOCAINE HCL HYDRATE;LIDOCAINE HYDROCHLORIDE, MONOHYDRATE;2,6-acetoxylidide,2-(diethylamino)-,hydrochloride,hydrate; acetamide,2-(diethylamino)-n-(2,6-dimethylphenyl)-,monohydrochloride,monoh;diethylaminoacet-2,6-xylididehydrochloridemonohydrate;dolicaine
Assay (%):≥99.5
CAS: 6108-05-0
MF: C14H25ClN2O2
MW: 288.81
Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Sodium channel;hydrochloride . hydrate;Other APIs
solubility H2O: soluble
form solid
color white

Usage:

Na+ channel blocker. Hydrochloric acid lidocaine effect of amide local anesthetic. As a local anesthetic and antiarrhythmic drugs. Mainly used for:
(1) infiltration anesthesia, epidural anesthesia, anesthesia (including mucosal surface anesthesia used in thoracoscopy or abdominal operation) and nerve conduction block.
(2) in treatment of acute myocardial infarction (AMI) after ventricular premature beats and ventricular Beckoning tachycardia, ventricular arrhythmia and digitalis poisoning, cardiac surgical operation, cardiac catheter induced, but usually is not valid for supraventricular arrhythmia.

Lidocaine, CAS: 137-58-6

99% Lidocaine Local Anesthetic Powder Lidocaine Base Pain Killer CAS 137-58-6

Lidocaine
CAS: 137-58-6
Assay: 99%
Appearance: White crystalline powder
Packing: 25kg/drum
EINECS: 205-302-8
Molecular Formula: C14H22N2O
Molecular weight: 234.34
Manufacturer: YUANCHENG
Usage: Topically used to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery.

Product Description:

Lidocaine, xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery.It is on the World Health Organization’s List of Essential Medicines, a list of the most important medications needed in a basic healthcare system.

Lidocaine is the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated. Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.

Product Applications:

The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for subdural and epidural anesthesias; lidocaine, though, has the advantage of a rapid onset of action.

Epinephrine vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine, almost doubling the duration of anaesthesia. For surface anesthesia, several available formulations can be used e.g. for endoscopies, before intubations, etc. Buffering the pH of lidocaine makes local freezing less painful.[2] Lidocaine drops can be used on the eyes for short ophthalmic procedures.

Relative insensitivity to lidocaine is genetic. In hypokalemic sensory overstimulation, relative insensitivity to lidocaine has been described in people who also have attention deficit hyperactivity disorder.In dental anesthesia, a relative insensitivity to lidocaine can occur for anatomical reasons due to unexpected positions of nerves. Some people with Ehlers-Danlos syndrome are insensitive to lidocaine.

Lidocaine, along with ethanol, ammonia, and acetic acid, has also been proven to be effective in treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge

Lidocaine crosses the blood-brain and placental barriers, presumably by passive diffusion.
Lidocaine is metabolized rapidly by the liver, and metabolites and unchanged drug are excreted by the kidneys. Biotransformation includes oxidative N-dealkylation, ring hydroxylation, cleavage of the amide linkage, and conjugation. N-dealkylation, a major pathway of biotransformation, yields the metabolites monoethylglycinexylidide and glycinexylidide. The pharmacological/toxicological actions of these metabolites are similar to, but less potent than, those of Lidocaine. Approximately 90% of Lidocaine administered is excreted in the form of various metabolites, and less than 10% is excreted unchanged. The primary metabolite in urine is a conjugate of 4-hydroxy-2, 6-dimethylaniline.