Procaine HCL Local Anesthetic Drugs Procaine Hydrochloride Pain Reliever CAS 51-05-8
CAS NO.: 51-05-8
Appearance: White crystalline powder
Usage:Procaine is a kind of local anesthetics. With low toxicity but quick and safe effects, procaine is suitable for local anesthesia, applied to the eye, ear, nose, teeth and other department operation, used for infiltration anesthesia, anesthesia and closed therapy supervisor. Procaine is also used in the production of procaine penicillin.
Procaine is a local anesthetic drug of the amino ester group.It is used primarily to reduce the pain of Intramuscular injection of penicillin, and it is also used in dentistry.Owing to the ubiquity of the trade
Name Novocain, in some regions procaine is referred to generically as novocaine.It acts mainly by Being a sodium channel blocker.Today it is used therapeutically in some countries due to its Sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.
Procaine was first synthesized in 1905,shortly after amylocaine. It was created by the German chemist Alfred Einhorn who gave the chemical the trade name Novocaine, from the Latin nov- (meaning new) and -caine, a common ending for alkaloids used as anesthetics.
It was introduced into medical use by surgeon Heinrich Braun.Prior to the discovery of Amylocaine and procaine, was the most commonly used local anesthetic.Einhorn wished his New discovery to be used for amputations, but surgeons preferred general anesthetic.Dentists,However, found it very useful.Einhorn was displeased by this and spent many years touring Dental schools to advise them not to use it.
Procaine is a kind of local anesthetics.With low toxicity but quick and safe effects, procaine is suitable for local anesthesia, applied to the eye, ear, nose, teeth and other department operation, used for infiltration anesthesia, anesthesia and closed therapy supervisor.Procaine is also used in the production of procaine penicillin.Procaine causes loss of feeling (numbness) of skin and mucous membranes.Procaine is used as an injection during surgery and other medical and dental procedures.
Hormones and Regulation of Endocrine Function of Drug, Regulating Water and Salt, Electrolyte and Acid-Base Balance of Medicine, Anesthetic and Adjuvant, Blood System Agents, Drug Treatment of Mental Disorder, Visceral System Medication, Cardiovascular Agents, Respiratory System Agents, Disinfectant and Preservatives.
Procaine HCl is a local anesthetic drug of the amino ester group.It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry.Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine.It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion enhancing, and mood enhancing effects.
Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.
Application of procaine leads to the depression of neuronal activity.The depression causes the nervous system to become hypersensitive producing restlessness and shaking, leading to minor to severe convulsions.Studies on animals have shown the use of procaine led to the increase of dopamine and serotonin levels in the brain.Other issues may occur because of varying individual tolerance to procaine dosage.Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed.Procaine may also induce weakening of the myocardium leading to cardiac arrest.
Procaine can also cause allergic reactions causing the individuals to have problems with breathing, rashes, and swelling.Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA.About one in 3000 people have an atypical form of pseudocholinesterase, which does not hydrolyze ester anesthetics such as procaine, resulting in a prolonged period of high levels of the anesthetic in the blood and increased toxicity.
How it works?
Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.
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