Ibutamoren (MK-677)

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Description

Mk-677 Ibutamoren Sarms Powder for Muscle Growth CAS 159752-10-0 Mk-677 Ibutamoren

MK-677( Ibutamoren)
Synonyms: Ibutamoren, CHEMBL13817, S1151_Selleck, MK-677
CAS No.: 159752-10-0
Molecular Weight: 624.77
Molecular Formula: C28H40N4O8S2
Purity: 99%
Package: Be packed according to the customer requirements and packaging specifications.
Appearance: White crystalline powder
Storage; Store at -20° C
Specificity: MK-677 selectively binds GH secretagogue receptors in certain tissues.
Purity: >99% (HPLC analyzed).
Stability: Store at at 20 °C in dry place until the expiration date.
Source: Chemical Synthesis
Half-life: 24 hours

Description:

Ibutamoren (developmental code names MK-677, MK-0677, L-163,191) is a non-peptidic, potent, long-acting, orally-active, and selective agonist of the ghrelin receptor and a G-H secretagogue,mimicking the G-H-stimulating action of the endogenous hormone ghrelin.It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including G-H and insulin-like IGF-1, but without affecting cortisol levels.It is currently under development as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with G-H deficiency,and human studies have shown it to increase both muscle mass and bone mineral density,making it a promising therapy for the treatment of frailty in the elderly.It also alters metabolism of body fat and so may have application in the treatment of obesity.

Nutrobal (MK-677) is an orally administrated growth / hormone secretagogue originally developed by Reverse Pharmacology. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete . In other words, MK-677 could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn’t require any injections nor does it have any side effects like GHRP-6. This GHS (Growth / Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.

Technically, MK-677 is not a GH peptide at all, but a selective androgen receptor modulator (S.A.R.M). Most people, when they think of S.A.R.M’s, tend to think of steroid-like drugs such as Ostarine or S4, but S.A.R.M’s aren’t limited to steroid mimetics alone. Rather, they can have a wide range of effects in the body, serving as fat burners (GW-501516), muscle builders (LGD-4033), and in the case of MK-677, GH elevating agents.

Application area:

An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARd agonist. Exhibits selectivity for PPARd compared t
Usage An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells.

Effect:

–Inhibits the signaling of somatostatin receptors
–Slows down the activity of somastostatin in the system
–Improves somatotroph signaling in GHRH
–Amplifies and increases the overall production and release of GHRH

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