Gamma-butyrolactone (GBL)

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Description

Product Name: Gamma-butyrolactone(GBL)
CAS: 96-48-0
MF: C4H6O2
MW: 86.09
Purity:99.9%
Chemical Properties: colourless oily liquid
Usage: r-butyrolactone is one kind of important fine chemicalintermediate, simultaneously also is one
kind of performance fine highboiling point solvent, ideal antioxidant, plasticizer,extracting agent,
absorbent, dispersing agent, solid stain, Coagulation Reagent.
General Description Clear colorless oily liquid with a pleasant odor.
Intermediate in the synthesis of polyvinylpyrrolidone, DL-methionine, piperidine, phenylbutyric acid, thiobutyric acids. Solvent for polyacrylonitrile, cellulose acetate, methyl methacrylate polymers, polystyrene. Constituent of paint removers, textile aids, drilling oils.

gamma-Butyrolactone(GBL) Applications:

1). Used to produce a-pyrrolidone, 1-Methyl-2-pyrrolidinone, polyvinyl pyrrolidone, and α -Acetyl-γ -butyrolactone;
2). used as anaesthetic and tranquilizer, used to produce ciprofloxacin and interferon, as the
intermediate of vitamin and rolicyprine;
3). As antioxidant, plasticizer, extractant, adsorbent, dispersant, fixative and curing agent;
4). Used in battery, capacitor and development of color film.

gamma-Butyrolactone(GBL) introduction:

Gamma-Butyrolactone (γ-butyrolactone or GBL) is a hygroscopic colorless liquid with a weak
characteristic odor which is soluble in water. GBL is a common solvent and reagent in chemistry as
well as being used as a flavouring, as a cleaning solvent, as a superglue remover, and as a solvent
in some wet aluminium electrolytic capacitors. In humans it acts as a prodrug for GHB, and it is used
as a recreational intoxicant with effects similar to alcohol.

GBL is a lactone. It is hydrolyzed under basic conditions, for example in a sodium hydroxide solution
into sodium gamma-hydroxybutyrate, the sodium salt of gamma-hydroxybutyric acid. Under acidic
conditions it forms an equilibrium mixture of both compounds. These compounds then may go on to
form a polymer. When treated with a non-nucleophilic base, like lithium diisopropylamide, GBL can
become an alpha-carbon nucleophile. The related compound caprolactone can be used to make a
polyester in this manner.

GBL is rapidly converted into GHB by paraoxonase (lactonase) enzymes, found in the blood. Animals which lack these enzymes exhibit no effect from GBL. GBL is more lipophilic (fat soluble)
than GHB, and so is absorbed faster and has higher
bioavailability. Because of these pharmacokinetic differences, GBL tends to be more potent and
faster-acting than GHB, but has a shorter duration; whereas the related compound 1,4-butanediol
(1,4-B) tends to be slightly less potent, slower to take effect but longer-acting than GHB.

GHB for Bodybuilding

GBL is converted to GHB shortly after entering the body. Both produce a feeling of euphoria and can reduce inhibitions and cause sleepiness. Gamma butyrolactone is a chemical. People use it as medicine. Be careful not to confuse gamma butyrolactone (GBL) with gamma hydroxybutyrate (GHB). Gamma-Butyrolactone + NaOH => Sodium Gamma-Hydroxy Butyrate (Na-GHB).

GHB has many potential therapeutic uses and is considered to have a very low toxicity profile. In some European countries, it’s used as a general anesthetic, for sleep disorders, an aid to childbirth and a treatment for alcoholism. It also is reported to be a great aphrodisiac.

Bodybuilders and other athletes have used GHB because of its ability to stimulate the pituitary to release growth hormone (GH).GHB should lower the secretion of the stress hormone cortisol, especially at night. This is perceived as a major benefit because cortisol release keeps increasing as the night goes on. t certainly makes sense that a relaxing agent should depress cortisol level.If you are in a state of acidosis because of your diet, this particular action of GHB will spare some of your muscle mass while permitting fat loss. The extra GH release due to GHB will also help you to get rid of the extra acid and therefore spare your muscle mass and glutamine. If you are not in a state of acidosis, this anti-catabolic action of GHB will not appear.

Relaxation, calming, increased mental clarity, fat loss, use as a body or muscle “builder,” recreational drug use, releasing growth hormone, improving athletic performance, trouble sleeping (insomnia), relieving depression and stress, prolonging life, improving sexual performance and pleasure, and other conditions.

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