Diphenhydramine Hydrochloride

描述

Diphenhydramine Hydrochloride Basic information
Product Name: Diphenhydramine Hydrochloride
Synonyms: Sleep-eze;Valdrene;Wehydryl;Ziradryl;N,N-DIMETHYL-N-(2-DIPHENYLMETHOXYETHYL)-AMMONIUM CHLORIDE;N-(2-DIPHENYLMETHOXYETHYL)-N,N-DIMETHYLAMIDE;N-[2-DIPHENYLMETHOXYETHYL]-N,N-DIMETHYLAMINE HYDROCHLORIDE;N-(2-DIPHENYLMETHOXYETHYL)-N,N-DIMETHYLAMMONIUM CHLORIDE
CAS: 147-24-0
MF: C17H22ClNO
MW: 291.82
Product Categories: Anilines, Aromatic Amines and Nitro Compounds;API intermediates;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;-;Histamine receptor;BENADRIL;Other APIs;On the central nervous activity inhibition of sedative hypnotic effect;API;Pharmaceutical intermediates
Diphenhydramine Hydrochloride
Description Diphenhydramine hydrochloride is an antihistamine drug having the chemical name 2-(Diphenylmethoxy)- N,N-dimethylethylamine hydrochloride. It occurs as a white, crystalline powder, is freely soluble in water and alcohol and has a molecular weight of 291.82.
The molecular formula is C17H21NO·HCl and the structural formula is as follows:
Diphenhydramine hydrochloride structural formula
Diphenhydramine hydrochloride in the parenteral form is a sterile, pyrogen-free solution available in a concentration of 50 mg of diphenhydramine hydrochloride per mL. The solutions for parenteral use have been adjusted to a pH between 5.0 and 6.0 with either sodium hydroxide or hydrochloric acid and contains 0.1 mg/mL benzethonium chloride as a germicidal agent.
Chemical Properties White or almost white, crystalline powder.
Uses Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine is categorized as an antihistaminic; sedative, hypnotic.
Uses antihistamine, sedative, treatment of allergic
Uses A histamine H1-receptor antagonist.
Uses H1-Histamine receptor antagonist. Antihistaminic; sedative, hypnotic

Diphenhydramine hydrochloride in the injectable form is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when diphenhydramine hydrochloride in the oral form is impractical.
antihistaminic: For amelioration of allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled, and for other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated.
Motion Sickness: For active treatment of motion sickness.
Antiparkinsonism: For use in parkinsonism, when oral therapy is impossible or contraindicated, as follows: parkinsonism in the elderly who are unable to tolerate more potent agents; mild cases of parkinsonism in other age groups, and in other cases of parkinsonism in combination with centrally acting anticholinergic agents.
Drug overdose Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. Stimulation is particularly likely in pediatric patients. Atropine-like signs and symptoms; dry mouth; fixed, dilated pupils; flushing; and gastrointestinal symptoms may also occur. Stimulants should not be used. Vasopressors may be used to treat hypotension.

Use in Neonates or Premature Infants: This drug should not be used in neonates or premature infants.
Use in Nursing Mothers: Because of the higher risk of antihistamines for infants generally, and for neonates and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.
Use as a Local Anesthetic: Because of the risk of local necrosis, this drug should not be used as a local anesthetic.
Antihistamines are also contraindicated in the following conditions: Hyper sensitivity to diphenhydramine hydrochloride and other antihistamines of similar chemical structure