Dexamethasone sodium phosphate

描述

Dexamethasone sodium phosphate Basic information
Product Name: Dexamethasone sodium phosphate
Synonyms: DEXAMETHASON SODIUM PHOSPHATE;DEXAMETHASONE SODIUM PHOSPHATE;DEXAMETHASONE PHOSPHATE SODIUM;DEXAMETHASONE PHOSPHATE DISODIUM SALT;1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-PHOSPHATE, DISODIUM SALT;9-FLUORO-11 BETA,17 ALPHA,21-TRIHYDROXY-16 ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE-21-(DIHYDROGENPHOSPHATE)DIS;Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, sodium salt (1:2), (11β,16α)-
CAS: 55203-24-2/2392-39-4
MF: C22H28FNa2O8P
MW: 516.4

Standard: Enterprise Standard, Pharmaceutical Grade
Assay: ≥98%
Appearance: white powder
Packaging : 1kg/aluminum foil bag

Product Categories: Immunomodulators and AntibioticsLipids;Steroids (C21) and Derivatives;Immune Cell Signaling and Blood;Immune System Regulation;Sterols;Pharmaceutical intermediate;-;API;HEXADROL;Hormone Drugs

Dexamethasone 21-phosphate disodium salt Usage
Summary Dexamethasone 21-phosphate disodium salt is a system glucocorticoid with anti-inflammatory properties, is the pro-drug which is converted to dexamethasone in vivo. It stimulates uptake of glutamine in the cerebral cortex and induces apoptosis. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways.
It is freely soluble in water, slightly soluble in ethanol, and insoluble in chloroform and in ether. It is an inhibitor of the sodium phosphate symporter and GR activator.
Additionally, it serves as an activator of food, medicine, glucocorticoid and anti inflammatory.
Anti-inflammatory drugs Dexamethasone sodium phosphate (DSP), chemical name 16a-methyl-11β,17a,21-trihydroxy-9a-fluoropregna-1,4-diene-3,20-dione-21-Phosphate disodium salt, belongs to the adrenal cortex hormones. It has the effect of antiphlogosis by stabilizing the lysosomal membrane, reducing the release of lysosomal hydrolase; inhibiting the formation of inflammation-induced material bradykinin, serotonin and prostaglandin, increasing the stability of mast cells particles, reducing the release of histamine, concentrate blood vessels, stop white blood cells and macrophages from migrating outside of the blood vessels, etc. It can inhibit macrophage function to play immunization function and inhibit the formation of fibroblasts which is conducive to prevent corneal scar. When used for trauma, it can stop scar from forming and protect eyesight. It can inhibit or reduce the formation of new vessel in the cornea and conjunctiva disease and alleviate rejection reaction and scar formation in local use. In clinical treatment it can be used for autoimmune diseases, allergies, inflammation, rheumatism, asthma, ophthalmology and dermatology and other diseases.

 

Usage

Adrenal corticosteroids drug, anti-inflammatory, anti-toxity, anti-allergy;
An anti-excitment glucocorticoid and also a precursor drug that can be converted into dexamethasone in body stimulating glutamate to be absorbed into the cerebral cortex. It is used as adrenal corticosteroids clinically with anti-inflammatory, anti-drug and anti-allergy effect.

Chemical Properties White or almost white, very hygroscopic powder.
Uses glucocorticoid, antiinflammatory

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