Dose-related data for vardenafil hydrochloride
Oral recommended dose:
The recommended starting dose is 10 mg and is taken approximately 25-60 minutes before sexual intercourse. In clinical trials, taking 4-5 hours before sexual intercourse, it still shows efficacy. The maximum recommended dose is used once a day. Vardenafil can be taken with or with food. Sexual stimulation is required as an instinctive response for treatment.
Depending on the efficacy and tolerability, the dose can be increased to 20 mg or reduced to 5 mg. The maximum recommended dose is 20 mg per day.
Patients with mild hepatic impairment (Child-Pugh A) do not need to adjust the dose; patients with moderate hepatic impairment (Child-Pugh B), due to reduced clearance of vardenafil, the recommended starting dose is 5 mg, followed by tolerance The pharmacodynamics gradually increased to 10 mg; the pharmacokinetic study of vardenafil in patients with severe liver damage (Child-Pugh C) has not been conducted.
No dose adjustment is required in patients with mild, moderate, or severe renal impairment. The vardenafil pharmacokinetic study of dialysis patients has not been conducted.
Some patients taking vardenafil and alpha-blockers at the same time may cause symptomatic hypotension. Only when patients are treated with alpha-blockers to stabilize their condition can they be combined. For patients who are stable with alpha-blockers, the dose of vardenafil should be 5 mg of the minimum recommended starting dose and tamsulosin can be taken at any time. When vardenafil is combined with other alpha-blockers, there should be some intermittent doses. For patients who have taken the optimal dose of vardenafil, the use of alpha-blockers should start with the lowest dose. For patients taking PDF5 inhibitors (including vardenafil), an increase in the alpha-blocker dose may cause a further drop in blood pressure in the patient.
Patients taking certain CYP3A4 inhibitors may need to adjust the dose of vardenafil (eg ketoconazole, itraconazole, ritonavir, indinavir and erythromycin).
When erythromycin is used at the same time, the maximum dose of vardenafil does not exceed 5 mg. When taking ketoconazole or itraconazole, the maximum dose of vardenafil should not exceed 5 mg. When the dose of ketoconazole and itraconazole exceeds 200 mg, vardenafil cannot be taken. Avoid taking the potent CYP3A4 inhibitors indinavir and ritonavir at the same time.