98% purity Remdesivir GS-5734 API CAS1809249-37-3 in stock china factory supplier
Name:Remdesivir (GS-5734)
CAS:1809249-37-3
Synonyms:GS-5734
Molecular Weight:602.58
Chemical Formula:C27H35N6O8P
Purity:98%min
Appearance: White powder
Packaging:1kg/bag, as requested
Shipping time: Within 72 hours after payment
Delivery time: 9-12 working days
Payment method: Western union / Moneygram /Bitcoin / TT
Delivery method: Express（FedEx,TNT,DHL,EMS） / Airport / Sea or according customer requirement
Free sample:available
Storage Condition:0 – 4 degree for short term (days to weeks), or -20 degree for long term (months)
Remdesivir Description: Remdesivir, also known as GS-5734, is a prodrug form of the antiviral nucleoside analog GS-44152. Upon entry into cells, remdesivir is metabolized into the nucleotide triphosphate GS-441524. Remdesivir inhibits murine hepatitis virus (MHV) with an EC50 of 30 nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74 nM in HAE cells after treatment for 24 h. GS-5734 inhibits both epidemic and zoonotic coronaviruses. It was developed as a treatment for filovirus infections such as Ebola virus disease and Marburg virus. Remdesivir was approved for treatment of COVID-19.
Remdesivir Application:Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucelotide prodrug.
Remdesivir (GS-5734), a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV.
Biological Activity
Viral RNA-dependent RNA polymerase inhibitor (RdRp) and broad spectrum antiviral nucleotide prodrug. Metabolized to active form, GS 441524 (Cat. No. 7227). Exhibits activity against a range of RNA viruses in vitro (EC50 values are 0.019, 0.07, 0.07 – 0.34, 0.086 – 0.14, and 23.15 μM against RSV, SARS-CoV, MERS-CoV, EBOV and SARS-CoV-2, respectively). Exhibits antiviral efficacy in animal models of MERS-CoV and EBOV infection.
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